Tests diagnostiques

• Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy

• The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis

• The Lymphocyte Transformation Test for Borrelia Detects Active Lyme Borreliosis and Verifies Effective Antibiotic Treatment

• An Enhanced ELISPOT Assay for Sensitive Detection of Antigen-Specific T Cell Responses to Borrelia burgdorferi

• A multiplex serologic platform for diagnosis of tick-borne diseases

• The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease

• Identification of Borrelia protein candidates in mouse skin for potential diagnosis of disseminated Lyme borreliosis

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Modes de contamination

Contaminations par transfusions sanguines

• Transfusion-Associated Lyme Disease – Although Unlikely, It Is Still a Concern Worth Considering

• Survival of Borrelia burgdorferi in blood products

• Lyme disease—another transfusion risk?

• Survival of Borrelia burgdorferi in human blood stored under blood banking conditions

• Tick-Borne Relapsing Fever

• Borrelia burgdorferi: survival in experimentally infected human blood processed for transfusion

• Transfusion-Associated Babesiosis in the United States: A Description of Cases

• Borrelia burgdorferi survival in human blood samples

• Babesia: An Emerging Infectious Threat in Transfusion Medicine (co-infection)

• Babesiosis Surveillance - CDC - Blood transfusion related transmission and perinatal transmission have also been reported

 

Contaminations materno-fœtales

• Lyme disease study raises possibility of mother-to-baby transmission

• Lyme Disease and Cases Occurring during Pregnancy

• Les femmes enceintes peuvent transmettre la maladie de Lyme

• 34 Years of Documentation of Maternal-Child Transmission of Lyme Disease and Congenital Lyme Borreliosis - A Review - by Sue Faber, RN, BScN

• A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn

• Congenital Transmission of Lyme and Tick-Born Diseases

• Contaminations par voie sexuelle

• Culture and identification of Borrelia spirochetes in human vaginal and seminal secretions

• Autres vecteurs

• Taons: Lyme Disease Transmitted by a Biting Fly

 

Persistance de la bactérie

• Late Disseminated Lyme Disease Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques

• Stationary Phase Persister/Biofilm Microcolony of Borrelia burgdorferi Causes More Severe Disease in a Mouse Model of Lyme Arthritis: Implications for Understanding Persistence, Post-Treatment Lyme Disease Syndrome (PTLDS), and Treatment Failure

• Variable manifestations, diverse seroreactivity and post-treatment persistence in nonhuman primates exposed to Borrelia burgdorferi by tick feeding

• Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

• Persistance de co-infection Bartonella avec tétracyclines ou macrolides car présence de formes persistantes

• Persister Development by Borrelia burgdorferi Populations In Vitro

• Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis

• Métamorphoses des spirochètes de la maladie de Lyme : Le phénomène des formes persistantes de borrélia

• Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice

• Borrelia Burgorferi Detected by Culture and PCR in Clinical Relapse of Disseminated Lyme Borreliosis

• Plus de 270 article scientifiques sur la persistance de la bactérie

• Persister mechanisms in Borrelia burgdorferi: implications for improved intervention

• Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells

• Persistence of Babesia microti Infection in Humans (co-infection)

• Isolation of live Borrelia burgdorferi sensu lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis

• Biofilm Structures of Borrelia burgdorferi Not Only Display More Tolerance to Lyme Antibiotics But Also Cause More Severe Pathology In a Mouse Arthritis Model

• Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis

• Metamorphoses of Lyme disease spirochetes: Phenomenon of Borrelia persisters

• Cultivation of Borrelia burgdorferi from Joint Fluid Three Months After Treatment of Facial Palsy Due to Lyme Borreliosis

• Intracellular persistence of Borrelia burgdorferi in human synovial cells (ceftriaxone incapable d'éradiquer les borrélias intracellulaires)

• Persistence of Lyme Disease Despite Antibiotic Treatment - 77 Peer-Reviewed Studies 1977-2012

• Complement Evasion in Borrelia spirochetes: Mechanisms and Opportunities for Intervention

 

Traitements

• Three-antibiotic cocktail clears "persister" Lyme bacteria in mouse study

• Clinical effects of fluconazole in patients with neuroborreliosis

• Efficacy of a long-term antibiotic treatment in patients with a chronic Tick Associated Poly-organic Syndrome

• Intérêt du disulfirame dans le traitement de la borréliose et de la babésiose (3 études de cas)

• Efficacy of a long-term antibiotic treatment in patients with a chronic Tick Associated Poly-organic Syndrome (TAPOS)

• Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library

• Retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease

 

Autre

• Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET

• Manganese and SOD in the Lyme disease pathogen

• Lymphocytes T - Baisse des CD57 dans le Syndrome de Fatigue Chronique et dans le Lyme chronique

• Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains → Explication du brouillard cérébral

• Des infections bactériennes intracellulaires systémiques (espèces de mycoplasmes, chlamydia, borrélia) identifiées dans les troubles neurodégénératifs (SEP, SLA) et du comportement (TED)

• Le suicide au sein des malades de Lyme et de maladies associées

• Le Lyme et la fonction dopaminergique

• Atteintes cardiaques de la maladie de Lyme

• Bibliographie de la GLA sur le Lyme

• Dysfonctionnement mitochondrial dans le Lyme

• IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis

• Borrelia burgdorferi Changes Its Surface Antigenic Expression in Response to Host Immune Responses